TOFACITINIB XR11 TABLET
Uses & Benefits
used alone or together with other medicines (eg, DMARDs) to treat moderate to severely active rheumatoid arthritis, active psoriatic arthritis, ulcerative colitis, ankylosing spondylitis
Details
Benefits
Tofacitinib is used to treat: Moderate to Severe Rheumatoid Arthritis (RA): For individuals who have not responded adequately to other anti-rheumatic treatments.Other Potential Uses (in some cases): Psoriatic arthritis.Ulcerative colitis.
How It Works
Tofacitinib is a Janus kinase (JAK) inhibitor that:
Blocks Janus Kinase Enzymes:
- These enzymes play a key role in the inflammatory process by triggering immune responses.
- Inhibition reduces inflammation, pain, and joint damage.
Modulates the Immune System:
- Helps control overactive immune responses seen in autoimmune conditions like rheumatoid arthritis.
Side Effects
Headache, Diarrhea, High blood pressure, Rash, Pneumonia, Bronchitis, Tuberculosis, Urinary tract infections (UTIs), Nasopharyngitis (inflammation of the throat and nasal passages), Herpes zoster (shingles), Cellulitis, Appendicitis, Anemia, Cough, Abdominal pain, Nausea, Vomiting, Fatigue, Peripheral edema (swelling of hands or feet)
Expert's Advice
- Combination Therapy:Tofacitinib may be used alone or with other medications like methotrexate.
- Time to Effect:2â8 weeks: Initial improvement in symptoms.3â6 months: Maximum benefits.
- Monitoring:Regular blood tests are essential to monitor:Liver functionKidney functionCholesterol levelsBlood cell counts
- Infections:Report any signs of infection, such as fever, cough, chills, or muscle aches, immediately.A tuberculosis test and chest X-ray may be required before starting treatment.
- Pregnancy and Breastfeeding:Inform your doctor if you are pregnant, planning to conceive, or breastfeeding, as Tofacitinib may not be safe.
- Avoid Certain Medications:Do not combine Tofacitinib with other immune-suppressing drugs like tocilizumab or similar medications.
Frequently Asked Questions
Q: Can Tofacitinib cause cancer?
Tofacitinib may increase the risk of certain cancers, such as lymphoma or skin cancers, due to its immune-suppressing effects. Inform your doctor if you have a history of cancer.
Q: How long does it take for Tofacitinib to work?
Initial improvement: 2â8 weeks.Full benefits: 3â6 months.
Q: Can Tofacitinib cause infections?
Yes, it can weaken the immune system, making you more susceptible to infections like: Tuberculosis, Shingles (Herpes zoster), Pneumonia, Urinary tract infections (UTIs)
Q: Should I get any tests before starting Tofacitinib?
Yes, you will need: Blood tests to check for anemia, liver function, and cholesterol levels. A tuberculosis test and chest X-ray.
Q: Can I take Tofacitinib with liver problems?
Mild to moderate liver impairment may be acceptable.Severe liver problems: Not recommended.
Q: Can Tofacitinib be taken with tocilizumab?
No, combining Tofacitinib with immune-modulating drugs like tocilizumab increases the risk of serious infections and complications.
Q: How long do I need to take Tofacitinib?
Tofacitinib is typically a long-term treatment.Do not stop taking it without consulting your doctor, as RA symptoms may worsen.